• Mustafa Sahin MD, PhD
    • Associate Professor
    •  
    • mustafa.sahin@childrens.harvard.edu
    • Tel 617-919-6258
    • Fax 617-730-0279
    • 300 Longwood Ave CLS 14073
    • Boston MA 02115
    •  

Publications
  1. Tsai, Peter T, Greene-Colozzi, Emily, Goto, June, Anderl, Stefanie, Kwiatkowski, David J, Sahin, Mustafa. Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice. Behavior genetics. 2012
  2. Tsai, Peter T, Hull, Court, Chu, Yunxiang, Greene-Colozzi, Emily, Sadowski, Abbey R, Leech, Jarrett M, Steinberg, Jason, Crawley, Jacqueline N, Regehr, Wade G, Sahin, Mustafa. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature. 2012
  3. Yuan, Elizabeth, Tsai, Peter T, Greene-Colozzi, Emily, Sahin, Mustafa, Kwiatkowski, David J, Malinowska, Izabela A. Graded Loss of Tuberin in an Allelic Series of Brain Models of TSC Correlates with Survival, and Biochemical, Histological, and Behavioral Features. Human molecular genetics. 2012
  4. Nie, Duyu, Sahin, Mustafa. A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures. Methods in molecular biology (Clifton, N.J.). 2012
  5. Lewis, William W, Sahin, Mustafa, Scherrer, Benoit, Peters, Jurriaan M, Suarez, Ralph O, Vogel-Farley, Vanessa K, Jeste, Shafali S, Gregas, Matthew C, Prabhu, Sanjay P, Nelson, Charles A, Warfield, Simon K. Impaired Language Pathways in Tuberous Sclerosis Complex Patients with Autism Spectrum Disorders. Cereb Cortex. 2011
  6. Sahin, Mustafa. Targeted treatment trials for tuberous sclerosis and autism: no longer a dream. Curr Opin Neurobiol. 2011
  7. Peters, Jurriaan M, Sahin, Mustafa, Vogel-Farley, Vanessa K, Jeste, Shafali S, Nelson, Charles A, Gregas, Matthew C, Prabhu, Sanjay P, Scherrer, Benoit, Warfield, Simon K. Loss of white matter microstructural integrity is associated with adverse neurological outcome in tuberous sclerosis complex. Acad Radiol. 2011
  8. Khwaja, Omar S, Sahin, Mustafa. Translational research: Rett syndrome and tuberous sclerosis complex. Current opinion in pediatrics. 2011
  9. Goto, June, Talos, Delia M, Klein, Peter, Qin, Wei, Chekaluk, Yvonne I, Anderl, Stefanie, Malinowska, Izabela A, Di Nardo, Alessia, Bronson, Roderick T, Chan, Jennifer A, Vinters, Harry V, Kernie, Steven G, Jensen, Frances E, Sahin, Mustafa, Kwiatkowski, David J. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proceedings of the National Academy of Sciences of the United States of America. 2011
  10. Han JM, Sahin M. TSC1/TSC2 Signaling in the CNS. FEBS Lett. 2011
  11. Tsai P, Sahin M. Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex. Curr Opin Neurol. 2011
  12. Zou T, Yang X, Pan D, Huang J, Sahin M, Zhou J. SMN Deficiency Reduces Cellular Ability to Form Stress Granules, Sensitizing Cells to Stress. Cell Mol Neurobiol. 2011
  13. Akten, Bikem, Kye, Min Jeong, Hao, Le T, Wertz, Mary H, Singh, Sasha, Nie, Duyu, Huang, Jia, Merianda, Tanuja T, Twiss, Jeffery L, Beattie, Christine E, Steen, Judith A J, Sahin, Mustafa. Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits. Proc Natl Acad Sci U S A. 2010
  14. Krishnan ML, Commowick O, Jeste SS, Weisenfeld N, Hans A, Gregas MC, Sahin M, Warfield SK. Diffusion Features of White Matter in Tuberous Sclerosis With Tractography. Pediatr Neurol. 2010
  15. Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, Dabora S, Codeluppi S, Pandolfi PP, Pasquale EB, Sahin M. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci. 2010
  16. Poduri A, Chitsazzadeh V, D'Arrigo S, Fedrizzi E, Pantaleoni C, Riva D, Busse C, Küster H, Duplessis A, Gaitanis J, Sahin M, Garganta C, Topcu M, Dies KA, Barry BJ, Partlow J, Barkovich AJ, Walsh CA, Chang BS. The syndrome of perisylvian polymicrogyria with congenital arthrogryposis. Brain Dev. 2009
  17. Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, Sahin M. Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner. J Neurosci. 2009
  18. Choi YJ, Di Nardo A, Kramvis I, Meikle L, Kwiatkowski DJ, Sahin M, He X. Tuberous sclerosis complex proteins control axon formation. Genes Dev. 2008
  19. Miyake N, Chilton J, Psatha M, Cheng L, Andrews C, Chan WM, Law K, Crosier M, Lindsay S, Cheung M, Allen J, Gutowski NJ, Ellard S, Young E, Iannaccone A, Appukuttan B, Stout JT, Christiansen S, Ciccarelli ML, Baldi A, Campioni M, Zenteno JC, Davenport D, Mariani LE, Sahin M, Guthrie S, Engle EC. Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. Science. 2008
  20. Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci. 2008
  21. Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell. 2008
  22. Datta AN, Hahn CD, Sahin M. Clinical presentation and diagnosis of tuberous sclerosis complex in infancy. J Child Neurol. 2008
  23. Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2007
  24. Jeste SS, Sahin M, Bolton P, Ploubidis GB, Humphrey A. Characterization of autism in young children with tuberous sclerosis complex. J Child Neurol. 2007
  25. Raju GP, Urion DK, Sahin M. Neonatal subependymal giant cell astrocytoma: new case and review of literature. Pediatr Neurol. 2007
  26. Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell. 2006
  27. Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, Greenberg ME. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 2005
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