The broad focus of the laboratory is the elucidation of mechanisms involved in maintenance of genomic stability in mammalian cells. More specifically, the laboratory studies the mechanism and control of antigen receptor variable region gene assembly (VDJ recombination) in developing B and T lymphocytes and the mechanism of immunoglobulin heavy chain class switch recombination (CSR) and somatic hypermutation in activated mature B lymphocytes.

1997 A.B., Harvard University, Cambridge, MA
2003 M.D., Harvard Medical School, Boston, MA
2006 Postdoctoral Fellow, MIT, Cambridge, MA
2009 Postdoctoral Fellow, NIH, Bethesda, Maryland

1. Pengcheng Zhu, Denis Martinvalet, Dipanjan Chowdhury, Dong Zhang, Ann Schlesinger, Judy Lieberman . The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1 Blood. 2008
2. Huang J, Li SJ, Chen XH, Han Y, Xu P. hnRNP-R regulates the PMA-induced c-fos expression in retinal cells. Cell Mol Biol Lett. 2008
3. Li J, Chen XH, Xiao PJ, Li L, Lin WM, Huang J, Xu P. Expression pattern and splicing function of mouse ZNF265. Neurochem Res. 2007
4. Peer D, Zhu P, Carman CV, Lieberman J, Shimaoka M. Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci USA. 2007
5. Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM, Feng Y, Palliser D, Weiner DB, Shankar P, Marasco WA, Lieberman J. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005